Plecasoft (Plecanatide 3 mg Tablets) - The Next Generation Laxative, which is 8 times more potent than Uroguanylin, bind to guanylate cyclase-C (GC-C) receptor on the proximal luminal surface of the intestinal epithelium. By increasing cGMP concentration, it results in the secretion of chloride and bicarbonate into the intestinal lumen, mainly through activation of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel. This causes increased intestinal fluid, which softens the stool, accelerates intestinal transit, and decreases abdominal pain sensation. Plecasoft is approved for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults.